Wednesday, April 15, 2020

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Coronavirus disease (COVID-19) - World Health Organization

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Latest Updates

April 15 (GMT)

  • 1512 new cases and 94 new deaths in Iran [source]
  • 3573 new cases and 324 new deaths in Spain [source]
  • 46 new cases and 1 new death in China [source]

January Timeline:
  • On January 31, the first 2 novel coronavirus cases in the UK, [18] the first 2 cases in Russia, [20] and the first case in Sweden and in Spain were reported. Canada reported its 4th case.
  • On Jan. 31, the United States
    • declared Coronavirus a Public Health Emergency
    • issued 14 days quarantine rules for US citizens entering the US from China (mandatory if entering from the Hubei province).
    • issued an order to deny entry to foreigners who have traveled to China within the past two weeks.
  • On January 30, the novel coronavirus total case count surpassed that for SARS (which affected 8,096 people worldwide).
  • On January 30, the World Health Organization declared the coronavirus outbreak a Global Public Health Emergency.
  • On January 30 CDC confirmed the first US case of human to human transmission[17].
  • Germany, Japan, Vietnam and the United States have reported cases in patients who didn't personally visit China, but contracted the virus from someone else who had visited Wuhan, China[15]. These cases of human to human transmission are the most worrisome, according to the WHO[16].
  • Wuhan (the city where the virus originated) is the largest city in Central China, with a population of over 11 million people. The city, on January 23, shut down transport links. Following Wuhan lock down, the city of Huanggang was also placed in quarantine, and the city of Ezhou closed its train stations. This means than 18 million people have been placed in isolation. The World Health Organization (WHO) said cutting off a city as large as Wuhan is "unprecedented in public health history."[12] and praised China for its incredible commitment to isolate the virus and minimize the spread to other countries.

How dangerous is the virus?

There are three parameters to understand in order to assess the magnitude of the risk posed by this novel coronavirus:

How contagious is the Wuhan Coronavirus? (Ro)

The attack rate or transmissibility (how rapidly the disease spreads) of a virus is indicated by its reproductive number (Ro, pronounced R-nought or r-zero), which represents the average number of people to which a single infected person will transmit the virus.
WHO's estimated (on Jan. 23) Ro to be between 1.4 and 2.5. [13]
Other studies have estimated a Ro between 3.6 and 4.0, and between 2.24 to 3.58. [23].
Preliminary studies had estimated Ro to be between 1.5 and 3.5. [5][6][7]
An outbreak with a reproductive number of below 1 will gradually disappear.
For comparison, the Ro for the common flu is 1.3 and for SARS it was 2.0.

Fatality Rate (case fatality ratio or CFR) of the Wuhan Coronavirus

See full details: Coronavirus Fatality Rate
The novel coronavirus' case fatality rate has been estimated at around 2%, in the WHO press conference held on January 29, 2020 [16] . However, it noted that, without knowing how many were infected, it was too early to be able to put a percentage on the mortality rate figure.
A prior estimate [9] had put that number at 3%.
Fatality rate can change as a virus can mutate, according to epidemiologists.
For comparison, the case fatality rate for SARS was 10%, and for MERS 34%.

Incubation Period (how long it takes for symptoms to appear)

Symptoms of COVID-19 may appear in as few as 2 days or as long as 14 (estimated ranges vary from 2-10 days, 2-14 days, and 10-14 days, see details), during which the virus is contagious but the patient does not display any symptom (asymptomatic transmission).

Age and conditions of Coronavirus cases

According to early estimates by China's National Health Commission (NHC), about 80% of those who died were over the age of 60 and 75% of them had pre-existing health conditions such as cardiovascular diseases and diabetes.[24]
According to the WHO Situation Report no. 7 issued on Jan. 27:
  • The median age of cases detected outside of China is 45 years, ranging from 2 to 74 years.
  • 71% of cases were male.
A study of 138 hospitalized patients with NCIP found that the median age was 56 years (interquartile range, 42-68; range, 22-92 years) and 75 (54.3%) were men.[25]
The WHO, in its Myth busters FAQs, addresses the question: "Does the new coronavirus affect older people, or are younger people also susceptible?" by answering that:
  • People of all ages can be infected by the novel coronavirus COVID-19.
  • Older people, and people with pre-existing medical conditions (such as asthma, diabetes, heart disease) appear to be more vulnerable to becoming severely ill with the virus.

Patient who died in the Philippines was a 44-year old male

The patient who died in the Philippines on February 2, in what was the first death occurring outside of China, was a 44-year-old Chinese man from Wuhan who was admitted on Jan. 25 after experiencing fever, cough, and sore throat, before developing severe pneumonia. In the last few days, “the patient was stable and showed signs of improvement, however, the condition of the patient deteriorated within his last 24 hours resulting in his demise." according to the Philippine Department of Health.

Serious Cases of 30 year old patients in France

As of Jan. 29, according to French authorities, the conditions of the two earliest Paris cases had worsened and the patients were being treated in intensive care, according to French authorities. The patients have been described as a young couple aged 30 and 31 years old, both Chinese citizens from Wuhan who were asymptomatic when they arrived in Paris on January 18 [19].

Age and Sex of the first deaths as reported by the China National Health Commission (NHC)

The NHC reported the details of the first 17 deaths up to 24 pm on January 22, 2020. The deaths included 13 males and 4 females. The median age of the deaths was 75 (range 48-89) years.[21]

WHO Risk Assessment: Global Emergency

See full details: WHO coronavirus updates
On January 30, the World Health Organization declared the coronavirus outbreak a Global Public Health Emergency.
For more information from the WHO regarding novel coronavirus: WHO page on Novel Coronavirus (2019-nCoV)

Comparisons:

  • Every year an estimated 290,000 to 650,000 people die in the world due to complications from seasonal influenza (flu) viruses. This figure corresponds to 795 to 1,781 deaths per day due to the seasonal flu.
  • SARS (November 2002 to July 2003): was a coronavirus that originated from Beijing, China, spread to 29 countries, and resulted in 8,096 people infected with 774 deaths (fatality rate of 9.6%). Considering that SARS ended up infecting 5,237 people in mainland China, Wuhan Coronavirus surpassed SARS on January 29, 2020, when Chinese officials confirmed 5,974 cases of the novel coronavirus (2019-nCoV). One day later, on January 30, 2020 the novel coronavirus cases surpassed even the 8,096 cases worldwide which were the final SARS count in 2003.
  • MERS (in 2012) killed 858 people out of the 2,494 infected (fatality rate of 34.4%).

Coronavirus Worldometer Sections:


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